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. 2022 Aug 26;13:953730. doi: 10.3389/fimmu.2022.953730

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Copyright © 2022 Tsuboi, Segawa, Yagishita, Toko, Honda, Kitada, Miki, Ohyama, Hagiwara, Kondo, Matsumoto and Sumida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation mechanisms of monocytes/macrophages in AOSD. Regarding the activation mechanisms of monocytes/macrophages in AOSD, the PAMPs and DAMPs-PRRs axis and NETs-DNA have been identified, in addition to IFNγ stimulation. NETs, neutrophil extracellular traps; PAMPs, pathogen-associated molecular patterns; DAMPs, damage-associated molecular patterns; PRRs, pattern recognition receptors; TLR, toll-like receptor; receptor for AGEs (advanced glycation end products) RAGE; NLRP, nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain.