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. 2022 Aug 26;13:953730. doi: 10.3389/fimmu.2022.953730

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Copyright © 2022 Tsuboi, Segawa, Yagishita, Toko, Honda, Kitada, Miki, Ohyama, Hagiwara, Kondo, Matsumoto and Sumida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed function of PLAC8 in IL-1β and IL-18 production (reference 46, modification)A schema illustrating how PLAC8 suppresses IL-1β and IL-18 production via enhancement of autophagy. Two steps might be needed for inhibition of IL-1β and IL-18 production by PLAC8 in primary monocytes. The first step is the upregulation of PLAC8, pro-IL-1β and pro-IL-18 in monocytes through LPS stimulation. The second step is the inhibition of pro-IL-1β and pro-IL-18 through the enhancement of autophagy by upregulated PLAC8, which is independent of caspase-1.