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. 2022 Sep 9;29:41. doi: 10.1051/parasite/2022042

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© D.B. Pirovich et al., published by EDP Sciences, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Sequence alignment of Schistosoma mansoni PGM (Sm) and select dPGMs from other organisms. Identical amino acid residues between sequences are shaded in black. Similar amino acid residues between sequences are shaded in gray. Important conserved residues are marked with arrowheads: the histidine residues (red), arginine residues (green), and glutamate residues (blue) have been reported to stabilize the active site and participate in binding and catalysis of the substrate 3-phosphoglycerate. The accession numbers of the aligned PGMs are as follows: Schistosoma mansoni Sm (OK490368.1), Schistosoma bovis Sb (RTG81826.1), Schistosoma japonicum Sj (Q8WT66), Clonorchis sinensis Cs (AAX29976.1), Drosophila melanogaster Dm (Q9VAN7), Homo sapiens Hs PGAM1 (P18669), Saccharomyces cerevisiae Sc (P00950), Escherichia coli Ec 2,3-bisphosphoglycerate-dependent PGM (P62707). (B) Phylogenetic tree of phosphoglycerate mutases. A phylogenetic tree of phosphoglycerate mutases constructed by Molecular Evolutionary Genetics Analysis (MEGA) Version 7.0.21 software using amino acid sequences obtained from the UniProt database. The optimal tree with the sum of branch length = 5.29 is shown. The scale bar represents the number of substitutions between sequences. Evolutionary distances were computed using the Poisson correction method. The analysis involved 19 amino acid sequences. The species names and UniProt accession numbers for the sequences are as follows: Schistosoma mansoni (UFA46002), Schistosoma japonicum (Q8WT66), Schistosoma bovis (RTG81826.1), Homo sapiens PGAM1 (P18669) and PGAM2 (P15259), Mus musculus PGAM1 (Q9DBJ1) and PGAM2 (O70250), Drosophila melanogaster (Q9VAN7), Escherichia coli 2,3-bisphosphoglycerate-dependent PGM (P62707) and 2,3-bisphosphoglycerate-independent PGM (P37689), Clonorchis sinensis (AAX29976.1), Fasciola hepatica (THD19385.1), Caenorhabditis elegans (G5EFZ1), Plasmodium falciparum (Q8IIG6), Onchocerca volvulus (I6LDA6), Biomphalaria glabrata (XP_013071129.1), Saccharomyces cerevisiae (P00950), Trypanosoma brucei (Q38AH1), and Nicotiana tabacum (P35494).