Table 2.

Inflammatory proteins with significant statistical differences in clinical symptoms among melancholic, atypical and anxious depression subtypes

Time/symptoms	Subtypes	Clinical symptoms	Protein label	AveExp. group 1	AveExp. group 2	LogFC	P value	Adjusted p value	Fold change	Regulation
Baseline/appetite	—	Decreased versus increased	TNF-α	7.728	6.417	1.311	0.018	0.063	2.482	Up
	M	Decreased versus increased	TNF-α	8.123	5.568	2.556	0.038	0.155	5.879	Up
Baseline/pain	M versus AN	Mild to moderate	TNF-α	8.240	6.833	1.407	0.042	0.146	2.651	Up
	AT versus AN	Severe	hsCRP	9.644	9.243	0.401	0.022	0.155	1.321	Up
	AN	None versus severe	hsCRP	9.725	9.243	0.483	0.001	0.010	1.397	Up
	AN	Mild to moderate versus severe	hsCRP	9.640	9.243	0.398	0.005	0.038	1.317	Up
8-week follow-up	M versus AT	No remission	IL-6	3.250	4.836	−1.586	0.018	0.063	0.333	Down
	AT versus AN	No remission	IL-6	4.836	3.085	1.751	0.016	0.109	3.366	Up
	AT	No remission versus remission	IL-6	4.836	2.184	2.651	0.001	0.006	6.283	Up
	AT	No remission versus remission	TNF-α	8.793	6.220	2.573	0.011	0.038	5.953	Up
12-week follow-up	AT	No remission versus remission	IL-6	4.258	2.044	2.214	0.022	0.077	4.639	Up

AveExp. group 1 and AveExp. group 2 represent the mean logarithmically transformed levels of the two groups involved in the comparison. In this study, the p value was adjusted by the method of Benjamini-Hochberg. Bold p values indicate <0.05.

AN, anxious depression subtype; AT, atypical depression subtype; hsCRP, high-sensitivity C reactive protein; IL, interleukin; M, melancholic depression subtype; TNF-α, tumour necrosis factor-α.