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. 2022 Sep 8;12(9):e058774. doi: 10.1136/bmjopen-2021-058774

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Numbers of participants. (A) The 35-year-old participant analysis: participants aged 35 years from 2008 to 2018. (B) The 2018 analysis: participants aged 35–65 years in 2018.