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. 2022 Sep 8;8(2):e002529. doi: 10.1136/rmdopen-2022-002529

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Regional association of transcriptome-wide association study (TWAS) hits. (A) Chromosome 12q13.2 regional association plot. (B) Chromosome 17q21.1 regional association plot. The top panel highlights all genes in the region. The marginally associated TWAS genes are shown in blue, and the jointly significant genes are shown in green. The bottom panel show a regional Manhattan plot of the genome-wide association study (GWAS) data before (grey) and after (blue) conditioning on the predicted expression of the green genes.