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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: Neuron. 2022 Feb 2;110(7):1173–1192.e7. doi: 10.1016/j.neuron.2022.01.006

Figure 3. Progressive S830(+) mHTT nuclear accumulation and aggregation in striatum and deeper cortical layers of BAC-CAG mice.

Figure 3.

(A) No detection of S830 signal in WT control mice.

(B) Nuclear accumulation and aggregation of mHTT in striatum of 12-month-old mice.

(C) mHTT Nuclear aggregates and inclusions in striatum of 18-month-old mice.

(D) Nuclear and cytosolic mHTT accumulation and aggregates in deeper cortical layers of 18-month-old mice.

(E–G) MSD assay for total, expanded, and aggregated mHTT forms in 2- to 18-month-old cortex, striatum, and cerebellum tissues. Results are shown as mean ± SEM, n = 4 for each age groups. *p < 0.05, ***p < 0.001. Scale bars, 20 mm. See also Figure S4