Table 2.
Impact of calcium chloride infusions on postoperative outcomes, univariate analysis
| Calcium Group (n = 66) | Control Group (n = 69) | p value | |
|---|---|---|---|
| Systolic blood pressure | |||
| Admission to ICU | 81 (72, 94) | 80 (72, 90) | 0.45 |
| 6 h | 70 (63, 77) | 72 (66, 79) | 0.25 |
| 12 h | 70 (65, 75) | 73 (66, 78) | 0.12 |
| 24 h | 71 (68, 77) | 73 (67, 82) | 0.40 |
| Diastolic blood pressure | |||
| Admission to ICU | 49 (43, 57) | 47 (40, 55) | 0.41 |
| 6 h | 46 (42, 50) | 47 (43, 51) | 0.72 |
| 12 h | 45 (40, 51) | 45 (40, 51) | 0.97 |
| 24 h | 43 (39, 49) | 45 (39, 50) | 0.84 |
| Heart rate | |||
| Admission to the ICU | 157 (150, 167) | 161 (148, 176) | 0.27 |
| 6 h | 169 (150, 176) | 165 (150, 179) | 0.95 |
| 12 h | 167 (157, 176) | 169 (151, 179) | 0.62 |
| 24 h | 157 (149, 171) | 159 (147, 168) | 0.54 |
| Cerebral NIRS | |||
| Admission to the ICU | 53 ± 12 | 55 + 16 | 0.48 |
| 6 h | 55 ± 12 | 57 ± 14 | 0.61 |
| 12 h | 59 ± 12 | 58 ± 13 | 0.61 |
| 24 h | 64 ± 13 | 63 ± 14 | 0.85 |
| Lactate | |||
| Admission to the ICU | 2.6 (2.0, 3.6) | 2.0 (1.5, 3.3) | 0.01 |
| 6 h | 2.5 (1.4, 3.3) | 1.5 (1.1, 2.4) | < 0.01 |
| 12 h | 2.3 (1.6, 3.0) | 1.7 (1.2, 2.4) | < 0.01 |
| 24 h | 1.5 (1.0, 2.0) | 1.6 (1.0, 2.3) | 0.65 |
| Vasoactive Inotropic Score (VIS) | |||
| Admission to the ICU | 10.5 + 4.7 | 10.1 ± 6.1 | 0.70 |
| 6 h | 13.6 ± 5.9 | 12.4 ± 6.8 | 0.28 |
| 12 h | 12.6 ± 6.1 | 12.9 ± 6.8 | 0.28 |
| 24 h | 13.1 ± 5.8 | 11.5 ± 6.7 | 0.16 |
| Max | 17.3 ± 6.0 | 14.9 ± 7.3 | 0.04 |
| VIS > 10 | 56 (90%) | 51 (74%) | 0.02 |
| CPB patients onlya | 53 (88%) | 44 (92%) | 0.75 |
| Maximum VIS > 15 | 42 (70%) | 38 (55%) | 0.08 |
| CPB patients onlyb | 39 (65%) | 33 (69%) | 0.84 |
| Renal injuryc | 2 (3%) | 3 (4%) | 1.0 |
| Acute liver injuryd | 6 (10%) | 5 (8%) | 0.76 |
| ECMO | 5 (8%) | 8 (12%) | 0.57 |
| Cardiac arrest | 5 (8%) | 6 (9%) | 1.0 |
| Duration of postoperative ventilation (days) | 4 (3, 7) | 4 (2, 8) | 0.93 |
| Time to postoperative feed initiation (days) | 4 (3, 5) | 3 (2, 5) | 0.11 |
| Hospital LOS (days) | 37 (25, 53) | 33 (21, 54) | 0.29 |
| Operative mortality | 4 (6%) | 8 (12%) | 0.37 |
| Composite outcome | 24 (39%) | 24 (35%) | 0.72 |
Categorical data are presented as n (%). Continuous data are presented as mean (standard deviation) for data that are normally distributed or median (interquartile range) for data that are not normally distributed
CPB cardiopulmonary bypass, ICU intensive care unit, NIRS near-infrared spectroscopy, VIS vasoactive inotropic score, ECMO extracorporeal membrane oxygenation, LOS length of stay
Denominator for patients who received CPB and calcium infusion = 60
Denominator for patients who received CPB and no calcium infusion = 48
Denominator for renal injury and calcium group = 62, denominator for control group = 69
Denominator for acute liver injury and calcium group = 60, denominator for control group = 63