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. 2022 Aug 8;7(15):e157336. doi: 10.1172/jci.insight.157336

Figure 4. DNM2 reduction improves mouse motor function of Speg-KO mice.

Figure 4

(A) Representative mouse activity maps from each genotype of mice and the corresponding activity type distribution graphs at 2 months of age. A clear improvement in ability to explore the arena is observed in Speg-rescue mice as compared with Speg-KO mice. R, resting time; S, slow movement; F, fast movement. (B) Distribution of mouse resting time, slow movement, and fast movement. Although not statistically significant, (C) Speg-rescue mice travel a longer horizontal distance (P = 0.08) than Speg-KO mice and (D) exhibit increased hind limb rearing behavior (P = 0.07) compared with Speg-KO mice. Control, n = 23; Speg-KO, n = 6; Speg-rescue, n = 9. *P < 0.05; **P < 0.01; ***P < 0.001; 1-way ANOVA with Tukey’s post hoc test.