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. 2022 Aug 22;7(16):e141193. doi: 10.1172/jci.insight.141193

Figure 1. RNA-Seq variant calling identified a psoriasis-associated SNP in 3′ UTR of the PCSK9 gene.

Figure 1

(A) SNP calling was performed on 2 separate psoriasis RNA-Seq data sets (12, 14), and ORs were calculated using the allele counting method. Fisher’s exact test was performed to calculate P values. Names of analyzed data sets are shown on the left with OR and P values on the right. The presence of SNP rs662145 C > T was associated with increased psoriasis risk. SNP rs662145-C constitutes the reference and minor allele, and SNP rs662145-T constitutes the alternative and major allele. (B) Meta-analysis of both RNA-Seq data sets using a random-effects model.