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(A) PCSK9 SNP linkage disequilibrium estimated from a psoriasis RNA-Seq data set (12) (see data set details in Supplemental Table 1). (B) Analysis of GWAS data from 2590 cases of psoriasis and 1720 controls (13) revealed a significant linkage between PCSK9 rs662145 C > T and psoriasis (P = 2.6 × 10–4).
