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. 2022 Aug 22;7(16):e141193. doi: 10.1172/jci.insight.141193

Figure 3. PCSK9 SNP rs662145 C > T is associated with altered expression of PCSK9 in cultured keratinocytes and nonlesional skin.

Figure 3

(A) In cultured keratinocyte cell lines and nonlesional skin, PCSK9 SNP rs662145 C > T HOMO phenotypes expressed lower levels of PCSK9 compared with PCSK9 SNP rs662145 C > T HET phenotypes. Box-and-whisker plots show normalized PCSK9 expression (log transformed reads on y axis). Each dot represents 1 keratinocyte line or skin sample. Differential gene expression was calculated using DESeq2. FDR-adjusted P values are displayed on each plot. (B) In cultured keratinocyte cell lines and nonlesional skin, there was no difference in the expression of PGK1, a housekeeping gene, between the reference allele and PCSK9 SNP rs662145 C > T HET and HOMO phenotypes. HOMO, homozygous; HET, heterozygous.