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. 2022 Aug 22;7(16):e141193. doi: 10.1172/jci.insight.141193

Figure 5. PCSK9 expression negatively correlates with IL36B and IL36G expression in keratinocytes and skin.

Figure 5

(A) In cultured keratinocyte cell lines, PCSK9 expression negatively correlated with IL36B and IL36G expression. PCSK9 expression did not correlate with PGK1 expression, a housekeeping gene. In these plots, each dot represents an in vitro cultured keratinocyte cell line under a different culture condition (control, IL-4, IL-13, IL-17A, IFN-α, IFN-γ, TNF-α, IL-4 and IL-13, IL-17A and IFN-γ, IL-17A, and TNF-α). Normalized log2 transformed reads for each gene are plotted on the x axis and y axis. Pearson’s correlation coefficients and P values are displayed on each plot. (B) Epidermal expression of PCSK9 and IL36G. Representative pictures of an IHC staining for PCSK9 and IL36G as well as the matching isotype controls in lesional skin of a patient with psoriasis (upper row) and healthy control nonlesional skin (lower row). The single arrow points to the basal layer. Double arrows point to the granular layer. Scale bar: 100 μm.