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. 2022 Aug 8;7(15):e154113. doi: 10.1172/jci.insight.154113

Figure 1. The Sema7aR145W heterozygous mutation promotes the progression of NAFLD in mice following HFD feeding.

Figure 1

Male WT and Sema7aR145W heterozygous (HE) mice were fed with normal chow diet (NCD) or HFD for 26 weeks. (A) The dynamic changes in the gains of body weights. (B) Liver weights. (C) The liver/body weight ratios. NCD-WT (n = 5), NCD-HE (n = 6), HFD-WT (n = 5), HFD-HE (n = 6). (D) Representative images (original magnification, ×200) of H&E, Oil Red O, and Sirius red staining of liver sections. (E) Quantitative analysis of the NAFLD activity scores (NASs). (F) Hepatic TG and Tch levels. The data were analyzed by 1-way ANOVA with Tukey’s post hoc tests or by Kruskal-Wallis test with Dunn’s post hoc test analysis. *P < 0.05 versus the WT mice with NCD; #P < 0.05 versus the Sema7aR145W heterozygous mice with NCD; $P < 0.05 versus the WT mice with HFD. TG, triglycerides; Tch, total cholesterol.