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. 2022 Sep 9;20:416. doi: 10.1186/s12967-022-03622-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — In the volcano plot, the red dot indicated a significantly upregulated protein and the blue dot indicated a significantly down regulated protein. The p-value was calculated using the two-sample t-test method. WhenP-value < 0.05, the difference expression amount changed by more than and less than 1.5 as a significantlyup-regulated and down-regulated change threshold, respectively. a When compared with healthy control, 332proteins were down-regulated and 169 proteins were up-regulated in CSCC. b In addition, a total of 246 proteinswere up-regulated and 154 proteins were down-regulated in the Bowen disease relative to the healthy control. c On the other hand, a total of 252 proteins were up-regulated and 104 proteins were down-regulated in the CSCCrelative to the Bowen disease