Table 4.
The 8 target proteins related biological functions or etiology in multiple tumors according to previous literature's reported (partial)
| Protein | Tumor | Regulated | Biological functions or etiology |
|---|---|---|---|
| COL1A1 | Lung cancer [12] | Up | COL1A1 was correlated with immune infiltrating levels, including CD4+ T cells, macrophage, neutrophil, and dendritic cell in lung cancer |
| Mesothelioma [13] | Up | COL1A1 expression was significantly correlated to the infiltration levels of CD4+ T cells, macrophages, and neutrophils in Mesothelioma | |
| COL3A1 | Ovarian carcinomas [14] | Up | COL3A1 higher expression was associated with shorter overall survival |
| CD36 | Ovarian cancer [15] | Up | The omental adipocytes could reprogram tumour metabolism through the upregulation of CD36 in Ovarian cancer cells |
| TNC | Colorectal cancer [16] | Up | Higher expression of TNC was correlated with a poorer prognosis in stages II and III of CRC. |
| Glioblastoma [17] | Up | Decreased TNC in the tumor microenvironment modulated behaviors of stromal cells, resulting in enlarged tumor blood vessels and activated microglia in tumors. Tenascin-C knockdown cells were sensitive to Temozolomide therapy | |
| FSCN1 | Renal cell carcinoma [18] | Up | Higher expression of FSCN1 led to an up-regulation of MMP9 and N-Cadherin in Renal cell carcinoma. Inhibition of PI3K/AKT or knockdown GSK-3βcould decreased the expression of FSCN1, and then attenuated Renal cell carcinoma invasion |
| Adrenocortical carcinoma [19] | Up | FSCN1 higher expression was associated with worse prognoses; Higher expression of FSCN1 was associated with the tumour microenvironment and immune signatures in Adrenocortical carcinoma | |
| ACTN1 | Oral SCC [20] | Up | Inhibition of ACTN1 could induce cell cycle arrest, promote apoptosis, and inhibit EMT and cell proliferation, migration, and invasion in the OSCC cell lines |
| Hepatocellular carcinoma [21] | Up | ACTN1 associated with Hippo signaling pathway activity and decreased Rho GTPases activities | |
| RAB31 | Pancreatic cancer [22] | Up | RAB31 higher expression was associated with shorter overall survival |
| Cervical cancer [23] | Up | RAB31 knockdown inhibited the epithelial-mesenchymal transition and cytoskeletal rearrangement in cervical cancer cells. Overexpression of RAB31 inhibited MAPK6 degradation | |
| SERPINB1 | Glioma [24] | Down | SERPINB1 inhibited glioma migration and invasion probably by dampening the expression of matrix metalloproteinase-2 |