Table 5.

The eight proteins involved the mainly KEGG pathways which those may associated with the etiology of CSCC development in our proteomics results

Protein	KEGG pathways
TNC	Focal adhesion; ECM-receptor interaction; Human papillomavirus infection; MicroRNAs in cancer; PI3K-Akt signaling pathway
FSCN1	MicroRNAs in cancer
SERPINB1	No enriched pathways
ACTN1	Focal adhesion; Viral carcinogenesis; Tight junction; Regulation of actin cytoskeleton; Adherens junction; Leukocyte transendothelial migration
RAB31	Endocytosis
COL3A1	Relaxin signaling pathway; Protein digestion and absorption; Platelet activation
COL1A1	Focal adhesion; Relaxin signaling pathway; Protein digestion and absorption; ECM-receptor interaction; Human papillomavirus infection; Proteoglycans in cancer; PI3K-Akt signaling pathway; Platelet activation
CD36	PPAR signaling pathway; Phagosome; ECM-receptor interaction; AMPK signaling pathway