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. 2022 Aug 26;10:931132. doi: 10.3389/fcell.2022.931132

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Copyright © 2022 Li, Long, Sun, Wu, He, Wang, Wang, Miao, Huang and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knocking down ST3GAL6 activates EGFR signaling and promotes the cancer cell invasion capacities of A549 and HCC827 cells. (A) Western blotting to investigate the activation of EGFR signaling in ST3GAL6 knockdown cancer cells. (B,C) The mRNA expression levels of ST3GAL6, MMP2, and MMP9 in A549 (B) and HCC827 cells (C) with ST3GAL6 knockdown. (D,E) Transwell assay on the cell invasion capacities of A549 (D) and HCC827 cells (E) with ST3GAL6 knockdown. Scale bar, 50 μm. Data are presented as mean ± SD of three independent experiments; Unpaired t test (two-tailed),∗∗∗p < 0.001.