Table 2.
Entorhinal CBF prediction of longitudinal performance in memory
| Memory | ||||
|---|---|---|---|---|
|
| ||||
| Estimate | SE | p | r | |
|
|
||||
| Intercept | 0.748 | 0.100 | <0.001 | 0.53 |
| Time | −0.103 | 0.021 | <0.001 | 0.38 |
| Age | −0.165 | 0.060 | 0.007 | 0.22 |
| Education | 0.047 | 0.054 | 0.394 | 0.07 |
| Sex | 0.310 | 0.112 | 0.006 | 0.22 |
| Pulse pressure | 0.107 | 0.057 | 0.062 | 0.15 |
| APOE ε4 | 0.018 | 0.130 | 0.889 | 0.01 |
| p-tau/Aβ | −0.753 | 0.136 | <0.001 | 0.42 |
| FDG-PET | 0.316 | 0.057 | <0.001 | 0.42 |
| Entorhinal CBF | 0.040 | 0.056 | 0.470 | 0.06 |
| Entorhinal CBF x Time | 0.064 | 0.022 | 0.004 | 0.23 |
APOE = apolipoprotein E; p-tau = phosphorylated tau; Aβ = β-amyloid; FDG-PET = fluorodeoxyglucose positron emission tomography; CBF = cerebral blood flow
Bold values are statistically significant (p<.05). Effect size (r-values) interpretation: small=0.10, medium=0.30, large=0.50.
Memory performance was measured using a composite score developed and validated within the ADNI sample [23]. The composite includes indices from the Rey Auditory Verbal Learning Test, Alzheimer’s Disease Assessment Scale – Cognitive Subscale, Logical Memory of the Wechsler Memory Scale–Revised, and the Mini-Mental State Examination.