Table 3.
Hippocampal CBF prediction of longitudinal performance in memory
| Memory | ||||
|---|---|---|---|---|
|
| ||||
| Estimate | SE | p | r | |
|
|
||||
| Intercept | 0.771 | 0.097 | <0.001 | 0.55 |
| Time | −0.098 | 0.022 | <0.001 | 0.37 |
| Age | −0.156 | 0.060 | 0.010 | 0.21 |
| Education | 0.054 | 0.055 | 0.326 | 0.08 |
| Sex | 0.311 | 0.111 | 0.006 | 0.23 |
| Pulse pressure | 0.100 | 0.057 | 0.083 | 0.14 |
| APOE ε4 | −0.014 | 0.132 | 0.916 | 0.01 |
| p-tau/Aβ | −0.765 | 0.135 | <0.001 | 0.43 |
| FDG-PET | 0.316 | 0.057 | <0.001 | 0.42 |
| Hippocampal CBF | −0.061 | 0.056 | 0.277 | 0.09 |
| Hippocampal CBF x Time | 0.009 | 0.024 | 0.700 | 0.03 |
APOE = apolipoprotein E; p-tau = phosphorylated tau; Aβ = β-amyloid; FDG-PET = fluorodeoxyglucose positron emission tomography; CBF = cerebral blood flow
Bold values are statistically significant (p<.05). Effect size (r-values) interpretation: small=0.10, medium=0.30, large=0.50.
Memory performance was measured using a composite score developed and validated within the ADNI sample [23]. The composite includes indices from the Rey Auditory Verbal Learning Test, Alzheimer’s Disease Assessment Scale – Cognitive Subscale, Logical Memory of the Wechsler Memory Scale–Revised, and the Mini-Mental State Examination.