Table 4.

Entorhinal CBF prediction of longitudinal entorhinal atrophy and white matter hyperintensity accumulation

	Entorhinal Thickness				WMH Volume
	Estimate	SE	p	r	Estimate	SE	p	r
Intercept	3.524	0.051	<0.001	0.99	0.626	0.046	<0.001	0.75
Time	−0.073	0.011	<0.001	0.52	0.053	0.006	<0.001	0.68
Age	−0.097	0.031	0.003	0.25	0.118	0.028	<0.001	0.33
Sex	−0.164	0.058	0.005	0.23	0.067	0.052	0.194	0.11
Pulse pressure	0.053	0.030	0.078	0.15	0.040	0.026	0.130	0.13
APOE ε4	0.026	0.068	0.706	0.03	−0.080	0.060	0.187	0.11
p-tau/Aβ	−0.182	0.071	0.011	0.21	0.258	0.064	<0.001	0.32
FDG-PET	0.143	0.030	<0.001	0.37	−0.055	0.027	0.042	0.17
Entorhinal CBF	0.040	0.029	0.171	0.11	−0.021	0.026	0.425	0.07
Entorhinal CBF x Time	0.039	0.012	0.001	0.28	−0.013	0.006	0.029	0.22

APOE = apolipoprotein E; p-tau = phosphorylated tau; Aβ = β-amyloid; FDG-PET = fluorodeoxyglucose positron emission tomography; CBF = cerebral blood flow

Bold values are statistically significant (p<.05). Effect size (r-values) interpretation: small=0.10, medium=0.30, large=0.50.