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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: J Alzheimers Dis. 2021;81(4):1711–1725. doi: 10.3233/JAD-201474

Table 5.

Hippocampal CBF prediction of longitudinal hippocampal atrophy and white matter hyperintensity accumulation

Hippocampal Volume WMH Volume

Estimate SE p r Estimate SE p r

Intercept 47.993 0.914 <0.001 0.97 0.626 0.045 <0.001 0.76
Time −1.256 0.125 <0.001 0.70 0.051 0.006 <0.001 0.66
Age −2.587 0.575 <0.001 0.35 0.120 0.028 <0.001 0.33
Sex −0.471 1.041 0.652 0.07 0.073 0.051 0.150 0.12
Pulse pressure 1.684 0.543 0.002 0.25 0.037 0.026 0.161 0.12
APOE ε4 −0.108 1.254 0.932 0.01 −0.095 0.060 0.116 0.13
p-tau/Aβ −3.586 1.282 0.006 0.23 0.264 0.063 <0.001 0.33
FDG-PET 2.966 0.545 <0.001 0.41 −0.056 0.026 0.034 0.16
Hippocampal CBF 0.591 0.523 0.260 0.09 −0.039 0.025 0.126 0.12
Hippocampal CBF x Time 0.141 0.123 0.280 0.10 0.003 0.007 0.649 0.05

APOE = apolipoprotein E p-tau = phosphorylated tau; Aβ = β-amyloid; FDG-PET = fluorodeoxyglucose positron emission tomography; CBF = cerebral blood flow

Hippocampal volume was normalized by total intracranial volume. Bold values are statistically significant (p<.05). Effect size (r-values) interpretation: small=0.10, medium=0.30, large=0.50.