Table 5.
Hippocampal Volume | WMH Volume | |||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Estimate | SE | p | r | Estimate | SE | p | r | |
|
||||||||
Intercept | 47.993 | 0.914 | <0.001 | 0.97 | 0.626 | 0.045 | <0.001 | 0.76 |
Time | −1.256 | 0.125 | <0.001 | 0.70 | 0.051 | 0.006 | <0.001 | 0.66 |
Age | −2.587 | 0.575 | <0.001 | 0.35 | 0.120 | 0.028 | <0.001 | 0.33 |
Sex | −0.471 | 1.041 | 0.652 | 0.07 | 0.073 | 0.051 | 0.150 | 0.12 |
Pulse pressure | 1.684 | 0.543 | 0.002 | 0.25 | 0.037 | 0.026 | 0.161 | 0.12 |
APOE ε4 | −0.108 | 1.254 | 0.932 | 0.01 | −0.095 | 0.060 | 0.116 | 0.13 |
p-tau/Aβ | −3.586 | 1.282 | 0.006 | 0.23 | 0.264 | 0.063 | <0.001 | 0.33 |
FDG-PET | 2.966 | 0.545 | <0.001 | 0.41 | −0.056 | 0.026 | 0.034 | 0.16 |
Hippocampal CBF | 0.591 | 0.523 | 0.260 | 0.09 | −0.039 | 0.025 | 0.126 | 0.12 |
Hippocampal CBF x Time | 0.141 | 0.123 | 0.280 | 0.10 | 0.003 | 0.007 | 0.649 | 0.05 |
APOE = apolipoprotein E p-tau = phosphorylated tau; Aβ = β-amyloid; FDG-PET = fluorodeoxyglucose positron emission tomography; CBF = cerebral blood flow
Hippocampal volume was normalized by total intracranial volume. Bold values are statistically significant (p<.05). Effect size (r-values) interpretation: small=0.10, medium=0.30, large=0.50.