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. 2022 Aug 26;15:947191. doi: 10.3389/fnmol.2022.947191

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Copyright © 2022 Thorne and Tumbarello.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alpha-synuclein influences mitochondrial transport and fission. Alterations in alpha-synuclein (α-syn) function may affect mitochondrial fission through direct effects on Drp1 activity and mitochondrial translocation, although the precise impact has not been clearly defined (indicated in gray). Oligomeric alpha-synuclein may also inhibit Drp1 trafficking to mitochondria as a result of alterations in actin cytoskeletal dynamics mediated by an association with the actin-cross linker spectrin. In addition, alpha-synuclein oligomers modulate Miro activity, either through promotion of Miro protein stability or retention in the outer mitochondrial membrane, influencing microtubule (MT) transport via dysregulation of kinesin or dynein activity.