Table 2.

Gene Set Enrichment Analysis top positive scores. Ten first upregulated Hallmark gene sets among RNA‐seq data for each condition according to their normalized enrichment score (NES). All enrichment scores have a nominal P‐value = 0 and a false discovery rate (FDR) q‐value < 0.0005.

Control		AR‐WT		AR‐Q641X		AR‐V7
HALLMARK	NES	HALLMARK	NES	HALLMARK	NES	HALLMARK	NES
E2F_TARGETS	10.13	E2F_TARGETS	8.15	MYOGENESIS	3.92	MYOGENESIS	3.34
G2M_CHECKPOINT	7.80	ANDROGEN_RESPONSE	7.90	ANDROGEN_RESPONSE	3.42	APICAL_JUNCTION	2.96
ANDROGEN_RESPONSE	6.27	MTORC1_SIGNALING	6.30	APICAL_JUNCTION	3.35	ANDROGEN_RESPONSE	2.72
MYC_TARGETS_V1	4.96	G2M_CHECKPOINT	6.16	HYPOXIA	2.64	MYC_TARGETS_V2	2.64
MYC_TARGETS_V2	4.92	MYC_TARGETS_V1	5.84	ESTROGEN_RESPONSE_EARLY	2.61	UV_RESPONSE_UP	2.49
MTORC1_SIGNALING	4.47	MYC_TARGETS_V2	5.09	EPITHELIAL_MESENCHYMAL_TRANSITION	2.47	GLYCOLYSIS	2.47
UNFOLDED_PROTEIN_RESPONSE	3.32	UNFOLDED_PROTEIN_RESPONSE	4.65	TNFA_SIGNALING_VIA_NFKB	2.43	ESTROGEN_RESPONSE_EARLY	2.35
MITOTIC_SPINDLE	2.58	GLYCOLYSIS	3.69	GLYCOLYSIS	2.40	EPITHELIAL_MESENCHYMAL_TRANSITION	2.31
DNA_REPAIR	2.31	UV_RESPONSE_UP	3.07	ESTROGEN_RESPONSE_LATE	2.05	HYPOXIA	2.28
CHOLESTEROL_HOMEOSTASIS	2.06	OXIDATIVE_PHOSPHORYLATION	3.02	UV_RESPONSE_UP	1.97	TNFA_SIGNALING_VIA_NFKB	2.27