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ppGpp modulates the activity of IMPDH in Actinobacteria and Firmicutes. Heatmap representation of the enzymatic percent activity (V 0 values normalized to the V 0 values in the absence of nucleotide) of BsIMPDH (a) and StcIMPDH (b) at different ATP versus ppGpp concentrations. The V 0 values used for normalization are BsIMPDH 32.9 and StcIMPDH 7.6 nM s−1. BsIMPDH, Bacillus subtilis IMPDH; IMPDH, IMP dehydrogenase; StcIMPDH, Streptomyces coelicolor IMPDH
