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. Author manuscript; available in PMC: 2023 Aug 19.
Published in final edited form as: ACS Chem Biol. 2022 May 20;17(8):2088–2098. doi: 10.1021/acschembio.2c00085

Figure 6. Active site of SxtA MT-DC F458H with dimethylmalonate and SAH.

Figure 6.

SAH and the methyl groups of dimethylmalonate are modeled, based on the structures in Figure 2d,e. The pro(R) methyl of dimethylmalonate clashes with the Ile204 side chain. Metal ligands (His372, Gln459, and Gln464), Asn243, Ile204, and Tyr208 are colored according to the domain of origin (Figure 2c), dimethylmalonate with white C and SAH with magenta C, metal coordination bonds as solid black lines, hydrogen bonds as dashed green lines and the steric clash as dotted yellow lines.