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Circulating tumor cell (CTC) enrichment technologies. (a) Density gradient centrifugation. (b) Microfluidic-based separation technology. (c) Different filtration systems depending on the size of blood cells used for separation and enrichment of CTC. (d) Adhesion is dependent on the affinity and specific binding of antibodies or aptamers (e.g., immune adhesion) to the CTC receptor.
