Table 7.
Effect of MPHE, hesperidin, and quercetin on histopathological scores of livers of NAPAP-administered rats.
| Histopathological changes | Score | Normal control | NAPAP | NAPAP+MPHE | NAPAP+hesperidin | NAPAP+quercetin |
|---|---|---|---|---|---|---|
| Inflammation | 0 | 6 (100%) | — | 2 (33.3%) | 4 (66.7) | 4 (66.7) |
| I | — | 1 (16.7%) | 2 (33.3%) | 2 (33.3%) | 1 (16.7%) | |
| II | — | 3 (50%) | 2 (33.3%) | — | 1 (16.7%) | |
| III | — | 2 (33.3%) | — | — | — | |
| Necrosis | 0 | 6 (100%) | — | 5 (83.3%) | 2 (33.3%) | 4 (66.7) |
| I | — | 1 (16.7%) | 1 (16.7%) | 2 (33.3%) | 2 (33.3%) | |
| II | — | 2 (33.3%) | — | 1 (16.7%) | — | |
| III | — | 3 (50%) | — | 1 (16.7%) | — | |
| Activated apoptosis | 0 | 6 (100%) | — | 3 (50%) | 2 (33.3%) | 5 (83.3%) |
| I | — | 1 (16.7%) | 3 (50%) | 4 (66.7) | 1 (16.7%) | |
| II | — | 4 (66.7) | — | — | — | |
| III | — | 1 (16.7%) | — | — | — | |
| Vacuolar degeneration | 0 | 6 (100%) | — | 2 (33.3%) | — | — |
| I | — | 1 (16.7%) | 1 (16.7%) | 1 (16.7%) | 3 (50%) | |
| II | — | — | — | 2 (33.3%) | 3 (50%) | |
| III | — | 5 (83.3%) | 3 (50%) | 3 (50%) | — | |
| Vascular congestion | 0 | 6 (100%) | — | 3 (50%) | 2 (33.3%) | 4 (66.7%) |
| I | — | 2 (33.3%) | 3 (50%) | 3 (50%) | 2 (33.3%) | |
| II | — | 2 (33.3%) | — | 1 (16.7%) | — | |
| III | — | 2 (33.3%) | — | — | — | |
| Stimulated Kupffer cell proliferation | 0 | 6 (100%) | — | 3 (15.0%) | 1 (16.7%) | 3 (15.0%) |
| I | — | — | 1 (16.7%) | 2 (33.3%) | 3 (15.0%) | |
| II | — | 2 (33.3%) | 2 (33.3%) | 2 (33.3%) | — | |
| III | — | 4 (66.7%) | — | 1 (16.7%) | — |
0: null; I: mild; II: moderate; III: severe lesions. The number of animals in each group is 6. The % in parentheses is the percent of animals in each grade of lesion.