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QDD ameliorates kidney fibrosis and inhibited the PERK-eIF2α-ATF4 pathway in db/db mice. (a) The expression and densitometry analysis of FN, TGF-β1, collagen type 4 (Col-IV), PERK, eIF2α, p-eIF2α and ATF4 (n = 3). (b) The mRNA levels of PERK, eIF2α, and ATF4 in renal tissue were determined by qRT-PCR (n = 6). Data are presented as the mean ± SD values. ∗P < 0.05 vs. db/m; #P < 0.05 vs. db/db.
