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. 2022 Sep 2;2022:9996946. doi: 10.1155/2022/9996946

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Copyright © 2022 Qin Ding et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Identification of cuproptosis-associated 18-lncRNAs with prognostic value and immune response in HNSCC patients. (a) A coexpression network of cuproptosis-related lncRNAs and genes was constructed and visualized. (b) 18 independent prognostic predictor lncRNA signatures with different expressions of HNSCC. (c) Box plot presents the differentially expressed cuproptosis-related lncRNAs between HNSCC and normal sample. (d) 501 HNSCC samples from the TCGA cohort were classified into 2 clusters using an unsupervised clustering method. (e) The Kaplan-Meier curve showed that patients in cluster 2 displayed a shorter overall survival than those in cluster 1. (f) Heat map of the prognostic characteristics and clinicopathological correlation of cuproptosis-related lncRNAs. (g) Correlation analysis of PD-L1 expression and 18 independent prognostic predictor lncRNA signatures. (h) Violin plot of immune-infiltrating lymphocytes between cluster 1 and cluster 2. (i) Box plot presents the differentially infiltrated CD8 T cells between cluster 1 and cluster 2. (j) Differences in ESTIMATE score between cluster 1 and cluster 2.