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. 2022 Apr 4;40(9):1378–1387. doi: 10.1038/s41587-022-01256-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Enriched mutations within the DddA gene of T7-DdCBE after PANCE against a GCA or GCG linker. T7-DdCBE-DddA11 was used as the input SP for PANCE. DddA mutations in the input SP are shown in beige. Mutations enriched after 9 or 12 PANCE passages are shown in blue. b-e, Heat maps of mitochondrial base editing efficiencies of HEK293T cells treated with canonical and evolved variants of (b) ND4.3-DdCBE, (c) ND5.4-DdCBE (d) ND5.2-DdCBE and (e) ATP8-DdCBE. Target spacing regions and split DddA orientations are shown for each base editor. For b-e, colors reflect the mean of n = 3 independent biological replicates.