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. 2022 Apr 4;40(9):1378–1387. doi: 10.1038/s41587-022-01256-8

Extended Data Fig. 2. DddA6 is compatible with split-G1333 and split-G1397 DdCBE orientations.

Extended Data Fig. 2

a-d, Mitochondrial base editing efficiencies of HEK293T cells treated with (a) ND1.1-DdCBE, (b) ND1.2-DdCBE, (c) ND2-DdCBE and (d) ND4-DdCBE. Target spacing regions and split DddA orientations are shown above each plot. Values and error bars reflect the mean±s.d of n = 3 independent biological replicates.