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. 2022 Sep 9;5:938. doi: 10.1038/s42003-022-03887-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Significantly more connections (Spearman correlations) were identified between microbial metabolites and species abundance as well as gut pathways during the reperfusion period than that in the ischemia period. c A global map linking significantly altered metabolites and pathways and their putative underlying key species. Metabolites in the red boxes were those sharply increased at IR6h compared to Sham. Red arrows indicated that the associated pathways were significantly increased at IIR6h compared to Sham and IIR0h.