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. 2022 Sep 10;13(9):781. doi: 10.1038/s41419-022-05223-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Western blot identifying the ZNF276 overexpression in MDA-MB-231 and SK-BR-3, ZNF276 knockdown in MCF-7 and ZNF276 knockout in UACC-812. B-C. CCK-8 assay measuring the effect of ZNF276 overexpression on cell proliferation in MDA-MB-231 (B) and SK-BR-3 (C) cells. D, E The effect of ZNF276 silencing (D) and knockout (E) on cell proliferation was evaluated by CCK-8 assay. F Cell proliferation ability of ZNF276 overexpressing cells was measured by clone formation assay. G Clone formation assay measuring the effect of ZNF276 silencing and knockout on cell proliferation. H ZNF276 overexpression affecting breast cancer tumor formation in the mammary fat pad of nude mice. I Measurement of tumor volume of the resected tumors from mice injected with ZNF276 overexpressing cells and control cells. J Statistical analysis of tumor weight of the resected tumors. K Immunohistochemical staining of Ki67 and ZNF276 in the resected tumors. Bar = 40 µm. *p < 0.05; **p < 0.01; ***p < 0.001.