Fig. 3.

Microbiota from CPSP rats with poor cognition induced cognitive impairment behavior and induced abnormal gut microbiota composition. A Schematic illustration of the experimental design. Effect of microbiota transplantation on the B mechanical sensitivity, C open field test, D Y-maze test, and E novel object preference test. N = 5 for the control, PBS, and unsus group, n = 10 for the sus group. Tukey’s post hoc tests; *p < 0.05, **p < 0.01. F Chaos index, α diversity. G Principal coordinates analysis (PCoA), β diversity. H The proportion of dominant species at the genus level (Circos). I Common species in the control, PBS-treat, susceptible donors-transferred, and susceptible donor–transferred samples at the genus level. J Species with different abundance at the phylum level