Fig. 1.

TOP2 catalytic inhibitors suppress ATRA-induced expression of CYP26A1, RARB, and CRABP2. SH-SY5Y cells were incubated with ATRA in the presence or absence of one of the TOP2 catalytic inhibitors, merbarone or ICRF-193 for the times indicated. Expression data was calculated relative to the control housekeeping gene PP1A. Significance testing was performed using 1-way ANOVA with Dunnett’s post-hoc test. Error bars are SDs