Table 2.
Percentage difference in kidney function biomarker concentrations at day two
| Cystatin C Cohort (n = 192) | Antibiotic Cohort (n = 739) | |||||
|---|---|---|---|---|---|---|
| VN + CP | VN + PT | % Differencea | VN + CP | VN + PT | % Differencea | |
| Cystatin C, mg/L, mean (SD) | ||||||
| Crude | 1.52 (1.22) | 1.51 (1.33) | − 1.26 (− 17.36, 17.97) | – | – | – |
| IPTW | − 5.63 (− 18.19, 8.86) | – | ||||
| Cystatin C:Creatinine ratio, mean (SD)b | ||||||
| Crude | 1.49 (0.83) | 1.23 (0.66) | − 17.57 (− 28.92, − 4.41) | – | – | – |
| IPTW | − 13.65 (− 24.52, − 1.23) | – | ||||
| Creatinine, mg/dL, mean (SD) | ||||||
| Crude | 1.15 (0.9) | 1.46 (1.19) | 19.79 (− 1.05, 45.01) | 1.16 (0.86) | 1.35 (0.93) | 17.8 (7.6, 28.9) |
| IPTW | 9.96 (− 3.19, 24.90) | 8.04 (1.21, 15.34) | ||||
| BUN, mg/dL, mean (SD) | ||||||
| Crude | 27.6 (21.2) | 26.9 (19.5) | − 3.97 (− 22.96, 19.69) | 25.9 (20.7) | 27.0 (18.9) | 6.91 (− 4.22, 19.33) |
| IPTW | − 9.05 (− 23.72, 8.45) | − 4.51 − 12.83, 4.59) | ||||
| BUN:Creatinine ratio, mean (SD)b | ||||||
| Crude | 23.8 (11.9) | 21.5 (10.9) | − 9.24 (− 15.99, − 1.99) | 25.5 (13.1) | 20.4 (9.5) | − 19.83 (− 30.82, − 7.10) |
| IPTW | − 12.16 (− 17.35, − 6.66) | − 17.86 (− 27.54, − 6.72) | ||||
VN + PT vancomycin + piperacillin–tazobactam, VN + CP vancomycin + cefepime
aComparison of biomarker concentrations at day two, adjusted for baseline concentration. Biomarker concentrations were log-transformed for analysis and model coefficients were exponentiated to provide the percentage difference between groups
bValues below one indicate creatinine increased to a greater extent than comparator biomarker (Cys-C or BUN)