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Loss of GSDMD or GSDME attenuated DSS-induced colitis. Mice were administrated with 2.5% DSS in drink water for 9 days. (A and B) Colon lysates were analyzed by immunoblotting. (C) Mouse body weight, recorded daily. (D) DAI. (E) Colon length. (F) Representative images of the colons. Data are mean ± SEM. N = 5 mice/group. *p < 0.05; **p < 0.005; ***p < 0.0005; ****p < 0.0001. One-Way ANOVA or Two-Way ANOVA. DAI, disease activity index; FL, full-length; ns, non-significant; WT, wild-type.
