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. 2022 Aug 28;56:102449. doi: 10.1016/j.redox.2022.102449

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Diabetes attenuates Nrf2 and impairs the survival and angiogenic function of EPCs. EPCs were isolated from healthy donors (Healthy-EPC) or diabetic patients (DM-EPC). (A) The Expression of Nrf2 and its downstream genes were detected by Western blot, and the quantitative data was normalized by the average of Healthy-EPCs for each protein; β-actin was used as a loading control. (B) The survival abilities of EPCs were determined by Annexin V/PI staining, and the quantitative data was expressed as the percentage of AnnexinV⁺/PI^– cells. (C) The angiogenic function of EPCs was evaluated by a Matrigel tube formation assay, and the quantitative data was normalized by the average tube length of Healthy-EPCs. n = 8 per group. Data shown in graphs represents the means ± SD. *p < 0.05, vs Healthy-EPC.