Table 3.
Antibacterial Scaffolds for oral tissue regeneration.
| Material | Fabrication method | Bacteria | Non-toxicity: cell line | Year | Ref |
|---|---|---|---|---|---|
| Scaffolds with antibiotics/antiseptics | |||||
| PDS scaffold loaded with metronidazole | Root canal space | P. gingivalis | Not studied | 2012 | [339] |
| Bimix antibiotic-containing polydioxanone-based polymer scaffolds | Electrospinning | E. faecalis P. gingivalis and F. nucleatum | Human dental pulp stem cells | 2014 | [340] |
| PDS + MET/CPFX scaffolds | Electrospinning | E. faecalis | Human dental pulp stem cells | 2015 | [341] |
| TAP-mimic polymer nanofibrous | Electrospinning | P. gingivalis | Not studied | 2016 | [342] |
| Chlorhexidine-releasing HAp scaffold incorporated with human serum albumin nanoparticles | Desolvation method | S.mutans | Not studied | 2020 | [343] |
| Scaffolds with antibacterial polymers | |||||
| Chitosan-based polyelectrolyte complex scaffolds | Electrostatic crosslinking | S. aureus and E. coli | MC3T3-E1preosteoblast cells | 2012 | [344] |
| Chitosan based scaffold | Freeze drying | P. gingivalis and S. mutans | human gingival epithelial cells | 2020 | [40] |
| Scaffolds with metals | |||||
| PCL scaffold loaded with Ag3PO4 and lidocaine | 3D printing | S. aureus and E. coli | MC3T3-E1preosteoblast cells | 2019 | [345] |
| Barium titanate reinforced polyvinyl-siloxane scaffolds | Commercial | S. epidermis | Not studied | 2020 | [346] |
| COL, chondroitin 4-sulfate, fibronectin and silver NP | Freeze-drying | F. nucleatum, P. gingivalis | Gingival fibroblasts, THP-1 monocytes/Chicken eggs | 2021 | [347] |
| Scaffolds with bioglass and antiseptics/metals | |||||
| Bioglass/chitosan scaffolds with chlorhexidine gluconate | Freeze-drying | E. faecalis | Wistar-Furth rat | 2020 | [348] |
| Nanometric Zinc doped bioactive glass | Sol-gel method | A. actinomycetemcomitans, P. gingivalis and P. intermedia | Not studied | 2020 | [349] |
| Antibacterial scaffolds by other strategies | |||||
| Epigallocatechin gallate scaffold | Crosslinking | Not specified | Human dental pulp stem cells | 2017 | [350] |
| Chitosan, calcium phosphate and GO | Blending | E. faecalis | Human dental pulp stem cells | 2021 | [351] |
| Carrageenan Based Injectable Hydrogel with Cissus quadrangularis extract | Solvent casting | Not studied | Not studied | 2022 | [352] |