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. 2022 Sep 9;13(9):778. doi: 10.1038/s41419-022-05128-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A, B, C EdU assay was performed to detect proliferation in 253 J and UM-UC-14 cells with OTUD5 knockdown and T24 cells with OTUD5 overexpression. **P < 0.01, ***P < 0.001. D Western blot was performed to determine the effect of OTUD5 on the expression of apoptosis markers (Bax, Cleaved-PARP, Cleaved-Caspase3) in bladder cancer cells. All data are presented as mean ± SD of three independent experiments. E The growth curves of xenografts in different groups. Tumor volumes were measured every three days from day 12 to day 30. ***P < 0.001. F Illustration of tumors excised from male nude mice in each group. G After 30 days, the nude mice were sacrificed, and UM-UC-14 cell xenografts were weighed. ***P < 0.001. H Immunohistochemical analysis of Ki67, Bax and Cleaved-PARP in tumor xenografts. I Western blot analysis of Bax, Cleaved-PARP and Cleaved-Caspase3 expression in tumor xenografts.