Table 2.
Top 50 features between discovery and replication cohorts.
| Feature order | Discovery: TwinsUK | Replication: QBB | Replicated* |
|---|---|---|---|
| 1 | Age | Age | Yes |
| 2 | BMI | BMI | Yes |
| 3 | Dihomo-linolenate (20:3n3 or n6) | Sex | Yes |
| 4 | Urate | Dihomo-linolenate | Yes |
| 5 | Cis-4-decenoyl carnitine | Urate | Yes |
| 6 | Lactate | Cis-4-decenoyl carnitine | Yes |
| 7 | Glucose | Lactate | No |
| 8 | Cortisol | Phenylacetylglutamine | Yes |
| 9 | Phosphate | Cortisol | No |
| 10 | Chloride | Histidine | Yes |
| 11 | Histidine | Gamma-glutamylphenylalanine | Yes |
| 12 | Glycine | Isobutrylcarnitine | No |
| 13 | HWESASXX* | 1-Oleoyl-GPE | No |
| 14 | 4-Androsten-3beta,17beta-diol monosulfate | 4-Androsten-3beta,17beta-diol disulfate1* | No |
| 15 | 1-Dihomo-linolenoyl-GPC (20:3n3 or 6)* | Chloride | No |
| 16 | N-Acetylglycine | N-Acetylglycine | Yes |
| 17 | 4-Androsten-3beta,17beta-diol disulfate1* | Creatine | Yes |
| 18 | 1-Arachidonoyl-GPE (20:4n6)* | Proline | Yes |
| 19 | Creatine | Phenol sulfate | Yes |
| 20 | Phenylacetylglutamine | Lysine | Yes |
| 21 | 1-Oleoyl-GPE (18:1) | Gamma-glutamyltyrosine | Yes |
| 22 | Fructose | Pentadecanoate | No |
| 23 | 4-Androsten-3beta,17beta-diol disulfate2* | 1-Arachidnoyl-GPE | Yes |
| 24 | Calcium | Glycerol | Yes |
| 25 | Potassium | Carnitine | No |
| 26 | Sex | 4-Androsten-3beta,17beta-diol disulfate2* | Yes |
| 27 | Dietary fat | 3-Hydroxybutyrate | No |
| 28 | Alanine | Leucine | No |
| 29 | Hydroxyphenylacetic acid monosulfate | 1,5-Anhydroglucitol | No |
| 30 | Dietary saturated fat | N-Acetylthreonine | No |
| 31 | 2-Aminobutyrate | Malate | No |
| 32 | Dietary trans fat | Arginine | No |
| 33 | Gamma-glutamyltyrosine | 1-Arachidnoyl-GPI | Yes |
| 34 | Lysine | Glutamine | Yes |
| 35 | Leucine | Pseudouridine | Yes |
| 36 | Phenol sulfate | Calcium | Yes |
| 37 | Isobutyrylcarnitine | Glycochenodeoxycholate | No |
| 38 | Glycerol | Cortisone | Yes |
| 39 | Gamma-glutamylphenylalanine | Glycocholate | Yes |
| 40 | Dietary sucrose | 1-Palmitoleoyl-GPC | No |
| 41 | Adrenate (22:4n6) | Tryptophan | Yes |
| 42 | Glycocholate | Adrenate | Yes |
| 43 | Pseudouridine | Glycerophosphorylcholine | Yes |
| 44 | Carnitine | Gamma-glutamylleucine | Yes |
| 45 | N-Acetylthreonine | Octanoylcarnitine | Yes |
| 46 | Pyroglutamine* | Bilirubin (E,E) | No |
| 47 | Dietary selenium | Octadecanedioate | No |
| 48 | 1-Arachidonoyl-GPI (20:4)* | 1-Palmitoleoyl-GPE | Yes |
| 49 | N-Acetylcarnosine | Stearate | No |
| 50 | Biliverdin | Idolepropionate | No |
*Feature replication column denotes if the feature in TwinsUK appeared in the top 50 features in QBB.