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. 2022 Aug 6;298(9):102344. doi: 10.1016/j.jbc.2022.102344

Table 1.

CYP8B1 binding and inhibition by azoles

Compound Structure Binding
 Inhibition
Shift in Soret peak KD (μM) Turnover at 80 μM (%) IC50 (μM)
Miconazole graphic file with name fx2.gif Type II 0.098 (0.085–0.11) 0.75 0.460 (0.315–0.629)
Econazole graphic file with name fx3.gif Type II 0.057 (0.048–0.068) 1.7 0.803 (0.663–0.963)
Tioconazole graphic file with name fx4.gif Type II 0.21 (0.18–0.24) 1.4 3.94 (3.13–5.06)
Clotrimazole graphic file with name fx5.gif Type II 1.6 (1.5–1.8) 6.8 7.36 (4.83–14.7)
Liarozole graphic file with name fx6.gif Type II 1.3 (1.2–1.5) 30 37.7 (25.5–61.8)
Ketoconazole graphic file with name fx7.gif Type II 1.3 (1.1–1.6) 16 N.D.
Fluconazole graphic file with name fx8.gif None N.D 95 N.D.

N.D., not determined.