Table. Randomized Clinical Trials With Patient and/or Family Representatives in Their Study Design.

Source	Journal	Category	Patient and/or family involvement	Roles
Befort et al,13 2021	JAMA	Public health or preventive medicine	REPOWER Rural Patient Advisory Board	Execution Informed trial design Reviewed recruitment, retention, and intervention materials Assisted with clinician trainings Provided a clear patient voice on the way obesity is treated in primary care
DeVore et al,14 2021	JAMA	Cardiovascular	Patient Engagement Committee	Execution End point selection: quality-of-life questionnaires; removal of incomplete, redundant, or outcomes of minimal value to people with heart failure Participant recruitment and retention
Drekonja et al,15 2021	JAMA	Infection	Community member representatives	Execution Involved in the protocol, consent form, and any subject-facing material (opt-out letters) Involved in creating participant-friendly information End point selection
Syversen et al,16 2021	JAMA	Rheumatology	Norwegian Rheumatism Association; Norwegian IBD Patient Organization; Psoriasis and Eczema Association of Norway	Execution Study design: is frequency of follow-up acceptable? End point selection: is outcome important to patients? Study conduct: information and motivation of patients to participate Translation Dissemination of results in webinars
Ghogawala et al,10 2021	JAMA	Neurology	Patient partners	Execution Study design
Andrade et al,11 2021	NEJM	Cardiovascular	Patient partners	Execution Study design: protocol development Translation Knowledge dissemination
Pusic et al,12 2021	Annals of Surgery	General surgery	Patient partners from the patient advocacy group Support Connection	Execution Study design: study materials; constructive feedback Study conduct: recruitment efforts

Abbreviations: IBD, inflammatory bowel disease; JAMA, Journal of the American Medical Association; NEJM, New England Journal of Medicine; REPOWER, Rural Engagement in Primary Care for Optimizing Weight Reduction.