Table 4.

Anti-inflammatory activity pinostrobin and complexes of pinostrobin in βCD and HPβCD against the edema induced by TPA in experimental animals. Data obtained at 2, 4, 6, and 24 h.

Compounds	Dose (mg)	2 h	4 h	6 h	24 h
Pinostrobin	1.5	0.20 ± 0.01	0.24 ± 0.01	0.25 ± 0.02	0.29 ± 0.02
Pinostrobin	2.0	0.20 ± 0.01 ∗	0.21 ± 0.01 ∗	0.26 ± 0.01 ∗	0.29 ± 0.01 ∗
Pinostrobin	3.0	0.19 ± 0.02 ∗∗	0.20 ± 0.01 ∗∗	0.25 ± 0.01 ∗∗	0.27 ± 0.01 ∗∗
Pinostrobin-βCD	1.5	0.18 ± 0.01 ∗∗∗	0.21 ± 0.01 ∗∗∗	0.24 ± 0.02 ∗∗∗	0.25 ± 0.01 ∗∗∗
Pinostrobin-βCD	2.0	0.17 ± 0.01 ∗∗	0.21 ± 0.02 ∗∗	0.24 ± 0.02 ∗∗	0.29 ± 0.02 ∗∗
Pinostrobin-βCD	3.0	0.18 ± 0.01 ∗∗∗	0.20 ± 0.02 ∗∗∗	0.21 ± 0.02 ∗∗∗	0.25 ± 0.02 ∗∗∗
Pinostrobin-HPβCD	1.5	0.18 ± 0.01 ∗∗∗	0.19 ± 0.02 ∗∗∗	0.2 ± 0.01 ∗∗∗	0.23 ± 0.01 ∗∗∗
Pinostrobin-HPβCD	2.0	0.18 ± 0.03 ∗∗∗	0.21 ± 0.01 ∗∗∗	0.21 ± 0.01 ∗∗∗	0.26 ± 0.01 ∗∗∗
Pinostrobin-HPβCD	3.0	0.18 ± 0.01 ∗∗∗	0.19 ± 0.02 ∗∗∗	0.20 ± 0.01 ∗∗∗	0.23 ± 0.01 ∗∗∗
βCD	13.0	0.22 ± 0.01	0.27 ± 0.01	0.35 ± 0.02	0.39 ± 0.0
HPβCD	15.0	0.23 ± 0.02	0.26 ± 0.01	0.32 ± 0.01	0.37 ± 0.01
Indomethacin	3.0	0.19 ± 0.00 ∗∗	0.20 ± 0.01 ∗∗	0.25 ± 0.01 ∗∗	0.27 ± 0.01 ∗∗
Vehicle	30	0.22 ± 0.01	0.26 ± 0.02	0.31 ± 0.02	0.40 ± 0.01

a. Units in percentage w/v.

Values as expressed how mean ± SD, p < 0.05 ∗, p < 0.01 ∗∗, p < 0.001 ∗∗∗, as compared to vehicle group. Two-way ANOVA and Dunnet's Post hoc test were performed. Pinostorobin-βCD: pinostrobin β-cyclodextrin complex, pinostrobin-HPβCD: Pinostrobin (2-Hydroxypropyl) -β-cyclodextrin complex, (n = 3).