Table 2.
Effective concentrations (EC50 and EC80, μM) of ascaphin-8 and its variants against the bacterial, mammal, and fungal liposome models
| Peptide | Bacterial model | Mammal model | Fungal model |
|---|---|---|---|
| EC50(μM) | |||
| Ascaphin-8 | 0.986 ± 0.159 | 3.87 ± 1.10 | 3.54 ± 0.60 |
| Var-K5 | 1.874 ± 0.217 | 3.58 ± 1.30 | 2.16 ± 0.33 |
| Var-D4 | 1.745 ± 0.305 | 5.99 ± 2.15 | 4.97 ± 1.07 |
| Var-Y | 1.908 ± 0.397 | 6.18 ± 1.77 | 4.68 ± 0.87 |
| EC80(μM) | |||
| Ascaphin-8 | 1.717 ± 0.277 | 5.41 ± 1.54 | 5.38 ± 0.91 |
| Var-K5 | 3.549 ± 0.334 | 5.01 ± 1.81 | 3.28 ± 0.50 |
| Var-D4 | 3.039 ± 0.531 | 8.36 ± 3.01 | 7.54 ± 1.63 |
| Var-Y | 3.322 ± 0.691 | 8.63 ± 2.47 | 7.10 ± 1.33 |