Figure 1.

A cartoon illustrating the curvature-coupled redistribution method. Beginning at the top left and proceeding counter-clockwise, a patch of multicomponent bilayer is simulated (represented above by purple and gray lipids in the top left). A set of dimer conformations are extracted and collected into states with common properties. Here, the cartoon represents divalent-cation-mediated interactions between an anionic lipid and its neighbors. The correlation of state (i.e., molecular structure) and curvature is recorded and compared with Helfrich/Canham theory. The mechanism of curvature sensitivity of a state is inferred from the correlation of structure and sampled curvature. To see this figure in color, go online.