Table 2.

univariate and multivariate analysis for predictors of progression-free survival

		Univariate analysis			Multivariate analysis
Variable	Subgroup	HR	95% CI	p-value	HR	95% CI	p-value
Age		0.98	0.98-1.00	0.096
Sex	Male	1
	Female	0.65	0.34-1.23	0.186
CEA	Normal (≤ 5)	1			1.0
	Elevated (>5)	1.56	0.83-2.91	0.165	3.05	1.21-7.72	0.018
Primary site	Colon	1
	Rectum	1.06	0.57-1.99	0.851
Site of Metastases	Liver only	1
	Other	1.30	0.68-2.50	0.432
No Metastases	≤2	1
	>2	1.60	0.87-2.97	0.133
PS	≤1	1
	>1	0.61	0.06-6.31	0.681
Hepatectomy	No	1
	Yes	0.43	0.11-1.64	0.219
Intent	Radical	1
	Palliative	2.55	1.36-4.78	0.004
Cycles XELOX		0.81	0.70-0.95	0.009	0.60	0.45-0.80	0.001
Metastases	Synchronous	1
	Metachronous	0.72	0.39-1.32	0.285
Location	Right	1			1.0
	Left	1.81	0.80-4.10	0.158	2.46	0.98-6.22	0.056
Colectomy	No	1			1.0
	Yes	0.36	0.17-0.78	0.009	11.0	0.997-121.09	0.050
Radiotherapy	No	1
	Yes	1.17	0.61-2.23	0.631

^*1.0 is the reference category