Table 4.
Predictive value of LDH for secondary endpoints
| Unadjusted | Adjusted | |||
|---|---|---|---|---|
| OR/HR (95% Cl) | P | OR/HR(95% Cl) | P | |
| MIMIC IIIa | ||||
| 1-year mortality | 2.69 (2.08–3.47) | < 0.001 | 2.08 (1.59–2.73) | < 0.001 |
| Prolonged ventilation | 3.86 (3.09–4.81) | < 0.001 | 3.02 (2.38–3.84) | < 0.001 |
| CRRT | 2.98 (2.16–4.12) | < 0.001 | 2.84 (1.85–4.36) | < 0.001 |
| ICU stay > 6 days | 3.97 (3.24–4.88) | < 0.001 | 3.22 (2.58–4.02) | < 0.001 |
| Hospital stay > 15 days | 2.84 (2.32–3.47) | < 0.001 | 2.24 (1.80–2.80) | < 0.001 |
| MIMIC IVb | ||||
| 1-year mortality | 3.27 (1.86–5.76) | < 0.001 | 1.99 (1.05–3.76) | 0.034 |
| Prolonged ventilation | 4.50 (3.25–6.23) | < 0.001 | 2.77 (1.90–4.04) | < 0.001 |
| CRRT | 3.78 (2.43–5.88) | < 0.001 | 2.92 (1.57–5.40) | 0.001 |
| ICU stay > 6 days | 3.55 (2.45–5.15) | < 0.001 | 2.37 (1.55–3.63) | < 0.001 |
| Hospital stay > 15 days | 4.98 (3.57–6.93) | < 0.001 | 3.05 (2.09–4.46) | < 0.001 |
The OR/HR was examined regarding the low LDH as reference
OR odds ratio, HR hazard ratio, 95% CI 95% confidence interval, MIMIC Medical Information Mart for Intensive Care, LDH lactate dehydrogenase, ICU intensive care units, CRRT continuous renal replacement therapy
aThe baseline model includes variables that are significant in univariate logistic proportional hazard analysis in MIMIC III, including ethnicity, SBP, heart rate, hypertension, CHD, heart failure, BUN, SCr, sodium, potassium, glucose, SAPS II, SOFA score(details shown in Additional file 2: Table S1)
bThe baseline model includes variables that are significant in univariate logistic proportional hazard analysis in MIMIC IV, including hypertension, heart failure, CKD, WBC, BUN, SCr, sodium, potassium, SAPS II (details shown in Additional file 2: Table S1)