Fig. 4.

An example of how cell types influence variant function. A In cell type A, TF is expressed and binds to the A allele in both the host genome and the MPRA construct. In the host genome with allele A, the gene is expressed. In the MPRA construct with allele A, the barcoded (BC) reporter gene is expressed. TF does not bind to the C allele, so the gene and BC associated with that allele are not expressed. B In cell type B, TF is not expressed, so the allele is not associated with BC expression